Učni načrt predmeta

Predmet:
Nanomedicina
Course:
Nanomedicine
Študijski program in stopnja /
Study programme and level		 Študijska smer /
Study field		 Letnik /
Academic year		 Semester /
Semester
Nanoznanosti in nanotehnologije, 3. stopnja 1 1
Nanosciences and nanotechnologies, 3rd cycle 1 1
Vrsta predmeta / Course type
Izbirni / Elective
Univerzitetna koda predmeta / University course code:
NANO3-932
Predavanja
Lectures		 Seminar
Seminar		 Vaje
Tutorial		 Klinične vaje
work		 Druge oblike
študija		 Samost. delo
Individ. work		 ECTS
15 15 15 105 5

*Navedena porazdelitev ur velja, če je vpisanih vsaj 15 študentov. Drugače se obseg izvedbe kontaktnih ur sorazmerno zmanjša in prenese v samostojno delo. / This distribution of hours is valid if at least 15 students are enrolled. Otherwise the contact hours are linearly reduced and transfered to individual work.

Nosilec predmeta / Course leader:
doc. dr. Nina Kostevšek
Sodelavci / Lecturers:
Jeziki / Languages:
Predavanja / Lectures:
slovenščina, angleščina / Slovenian, English
Vaje / Tutorial:
Pogoji za vključitev v delo oz. za opravljanje študijskih obveznosti:
Prerequisites:

Zaključen študij druge stopnje ustrezne (naravoslovne ali tehniške) smeri ali zaključen študij drugih smeri z dokazanim poznavanjem osnov področja predmeta (pisna dokazila, pogovor).

Completed second level studies in natural sciences or engineering or completed second level studies in other fields with proven knowledge of fundamentals in the field of this course (certificates, interview).

Vsebina:
Content (Syllabus outline):

- Uvod v nanomedicino: zgodovinski razvoj in najnovejša dognanja
- Tarčna dostava zdravil, biološke bariere v telesu in optimalna zasnova nanodelcev
- Slikovna diagnostika z uporabo nanoformulacij
- Teranostika
- Pregled nanozdravil po indikacijah in formulacijah
- Uporaba polimernih in anorganskih nanodelcev v nanomedicini
- Uporaba liposomov v nanomedicini
- Uporaba celičnih veziklov v nanomedicini
- Nanotehnologija za dostavo DNA in RNA
- Površinske modifikacije nanodelcev, aktivno tarčenje
- Računalniška metode za podporo eksperimentalnemu delu
- Personalizirana medicina
- Farmakokinetika, biološka porazdelitev in toksičnost
- Regulatorna toksikološka ocena nanozdravil, klinične raziskave
- Nanomedicina prihodnosti
Vsebina predmeta je sistematično zastavljena tako, da študentu zagotovi osnovne informacije in pregled najnovejših dognanj na področju nanomedicine. Hkrati pa spodbuja aktivno udeležbo, interdisciplinarno razmišljanje in interaktivno učenje preko skupinskih diskusij in študij konkretnih primerov.

- Introduction to Nanomedicine: history, progress and recent advances
- Targeted drug delivery, biological barriers in the body and optimal nanoparticle design
- Nanomaterials in imaging and diagnostics
- Theranostics
- Overview of nanomedicines by indications and formulations
- Applications of polymeric and inorganic nanoparticles in nanomedicine
- Applications of liposomes in nanomedicine
- Applications of cell-derived vesicles in nanomedicine
- Nanotechnology for DNA and RNA delivery
- Surface modification approaches towards stealth delivery and active targeting
- Computational methods to support experimental work
- Personalized medicine
- Pharmacokinetics, biodistribution and toxicity
- Regulatory Toxicological Assessment of Nanomedicines, Clinical trials
- Nanomedicine of the Future
The course content is systematically designed to provide students with basic information and an overview of the latest developments in the field of nanomedicine, while encouraging active participation, interdisciplinary thinking, and interactive learning through group discussions and case studies.

Temeljna literatura in viri / Readings:

Izbrana poglavja iz knjig / Selected chapters from books:
- »Nanomedicine: Technologies and Applications«, editor: Thomas J Webster. 2nd Edition - Elsevier, 2023, DOI: https://doi.org/10.1016/C2018-0-04438-2.
- »Nanomedicine: Innovations, Applications, and Breakthroughs in the Quest for Health and Medicine's Future«, editors: Vibhav Gautam, Rajiv Kumar, Krishna Das Manandhar, Swapnil C. Kamble, Springer Cham, 2024, DOI: https://doi.org/10.1007/978-3-031-72467-1.
- »Nanoparticles for Biomedical Applications«, editors: Eun Ji Chung, Lorraine Leon, Carlos Rinaldi, Elsevier, 2019, DOI: https://doi.org/10.1016/C2017-0-04750-X

Cilji in kompetence:
Objectives and competences:

CILJI:
- Razložiti in razpravljati o prednostih in izzivih nanomaterialov v medicinskih in farmacevtskih aplikacijah
- Opisati in kritično ovrednotiti različne vrste nanodelcev in nano-nosilcev ter njihovo uporabo v nanomedicini za diagnostiko in zdravljenje bolezni
- Opisati biološke prepreke ter pasivno in aktivno ciljanje, ki določajo učinkovitost dostavnih sistemov
- Ovrednotenje toksičnih, farmakokinetičnih in regulativnih vidikov za razvoj nano-formulacij za dostavo zdravil
- Poiskati, kritično ovrednotiti in predstaviti relevantno znanstveno literaturo s področja nanomedicine
- Skupinsko delo, aktivno sodelovanje v razpravah o trenutnih izzivih in najnovejših dognanjih na področju nanomedicine

KOMPETENCE:
- Samostojna uporaba interdisciplinarnih pristopov pri razvoju novih materialov na področju nanomedicine
- Kritično razmišljanje in sposobnosti reševanja problemov
- Upoštevanje etičnega vidika v raziskavah
- Razumeti pomen inovacij za izboljšanje kakovosti življenja

OBJECTIVES:
- Explain and discuss the advantages and challenges of nanomaterials in medical and pharmaceutical applications
- Describe and critically evaluate different types of nanoparticles and nanocarriers and their use in nanomedicine for the diagnosis and treatment of diseases
- Describe biological barriers and passive and active targeting that determine the effectiveness of delivery systems
- Evaluate toxicological, pharmacokinetic and regulatory aspects for the development of nanoformulations for drug delivery
- Search, critically evaluate and present relevant scientific literature in the field of nanomedicine
- Group work, active participation in discussions on current challenges and latest developments in the field of nanomedicine

COMPETENCES:
- Independent use of interdisciplinary approaches in the development of new materials in the field of nanomedicine
- Critical thinking and problem-solving skills
- Consideration of ethical aspects in research
- Understand the importance of innovation for improving the quality of life

Predvideni študijski rezultati:
Intendeded learning outcomes:

- Dokazati celovito poznavanje principov nanotehnologije in njihove uporabe v medicini
- Identificirati ključne izzive in omejitve pri razvoju in klinični uporabi nanomedicinskih tehnologij
- Kritično analizirati znanstveno literaturo in študije primerov s področja nanomedicine
- Učinkovito predstaviti ugotovitve raziskav s pisnim poročilom, predstavitvami in razpravami, prilagojenimi različnim občinstvom
- Vključevanje pridobljenega znanja v študentovo raziskovalno delo

- Demonstrate comprehensive knowledge of nanotechnology principles and their application in medicine
- Identify the key challenges and limitations in the development and clinical translation of nanomedicine technologies
- Critically analyze scientific literature and case studies in the field of nanomedicine
- Present research findings effectively through written reports, presentations, and discussions tailored to diverse audiences
- Incorporation of obtained knowledge in the student’s research work

Metode poučevanja in učenja:
Learning and teaching methods:

Interaktivna predavanja, seminar, delo v laboratoriju, konzultacije.

Interactive lectures, seminar, work in laboratory, consultations.

Načini ocenjevanja:
Delež v % / Weight in %
Assesment:
Seminar
30 %
Seminar
Zagovor seminarske naloge, pri katerem študent dokaže osvojitev temeljnih znanj predmeta na konkretnem primeru
30 %
Defense of a seminar work, in which the student demonstrates the understanding of subject knowledge using a concrete example
Ustni izpit
40 %
Oral exam
Reference nosilca / Lecturer's references:
1. 1. DELLA PELLE, Giulia, BOŽIČ, Tim, VUKOMANOVIĆ, Marija, SERŠA, Gregor, MARKELC, Boštjan, KOSTEVŠEK, Nina. Efficient siRNA delivery to murine melanoma cells via a novel genipin-based nano-polymer. Nanoscale advances. Sep. 2024, vol. 6, iss. 18, str. 4704-4723, ilustr. ISSN 2516-0230. DOI: 10.1039/D4NA00363B
2. 2. MA, Guanglong, KOSTEVŠEK, Nina, MARKELC, Boštjan, HUDOKLIN, Samo, ERDANI-KREFT, Mateja, SERŠA, Igor, ČEMAŽAR, Maja, MARKOVIĆ, Katarina, ŠČANČAR, Janez, et al. PD1 blockade potentiates the therapeutic efficacy of photothermally-activated and MRI-guided low temperature-sensitive magnetoliposomes. Journal of controlled release. [Print ed.]. 2021, vol. 332, str. 419-433, ilustr. ISSN 0168-3659. DOI: 10.1016/j.jconrel.2021.03.002
3. 3. KOSTEVŠEK, Nina, ABRAMOVIĆ, Irena, HUDOKLIN, Samo, ERDANI-KREFT, Mateja, SERŠA, Igor, SEPE, Ana, VIDMAR, Janja, ŠTURM, Sašo, ŠČANČAR, Janez, SPREITZER, Matjaž, KOBE, Spomenka, ŽUŽEK ROŽMAN, Kristina. Hybrid FePt/SiO2/AuFePt/SiO2/Au nanoparticles as theranostic tool : in vitro photo-thermal treatment and MRI imaging. Nanoscale. 2018, vol. 10, no. 3, str. 1308-1321. ISSN 2040-3364. DOI: 10.1039/C7NR07810B
4. 4. KOSTEVŠEK, Nina, ŠTURM, Sašo, ŽUŽEK ROŽMAN, Kristina, et al. The one-step synthesis and surface functionalization of dumbbell-like gold-iron oxide nanoparticles : a chitosan-based nanotheranostic system. Chemical communications. 2016, vol. 52, issue 2, str. 378-381. ISSN 1359-7345. DOI: 10.1039/C5CC08275G
5. 5. DELLA PELLE, Giulia, KOSTEVŠEK, Nina. Nucleic acid delivery with red-blood-cell-based carriers. International journal of molecular sciences. 2021, vol. 22, no. 10, str. 5264-1-5264-25. ISSN 1422-0067. DOI: 10.3390/ijms22105264