Učni načrt predmeta

Predmet:

Programirana celična smrt

Course:

Programmed Cell Death

Študijski program in stopnja / Study programme and level	Študijska smer / Study field	Letnik / Academic year	Semester / Semester
Nanoznanosti in nanotehnologije, 3. stopnja	Bioznanosti	1	1
Nanosciences and Nanotechnologies, 3rd cycle	Biosciences	1	1

Vrsta predmeta / Course type

Izbirni / Elective

Univerzitetna koda predmeta / University course code:

NANO3-823

Predavanja Lectures	Seminar Seminar	Vaje Tutorial	Klinične vaje work	Druge oblike študija	Samost. delo Individ. work	ECTS
30	30			30	210	10

*Navedena porazdelitev ur velja, če je vpisanih vsaj 15 študentov. Drugače se obseg izvedbe kontaktnih ur sorazmerno zmanjša in prenese v samostojno delo. / This distribution of hours is valid if at least 15 students are enrolled. Otherwise the contact hours are linearly reduced and transfered to individual work.

Nosilec predmeta / Course leader:

prof. ddr. Boris Turk

Sodelavci / Lecturers:

Jeziki / Languages:

Predavanja / Lectures:

slovenščina, angleščina / Slovenian, English

Vaje / Tutorial:

Pogoji za vključitev v delo oz. za opravljanje študijskih obveznosti:

Prerequisits:

Vsebina:

Content (Syllabus outline):

Temeljna literatura in viri / Readings:

Cilji in kompetence:

Objectives and competences:

Seznaniti študenta s pojmom celične smrti, z različnimi vrstami celične smrti, z mehanizmi delovanja in regulacije celične smrti, z vlogo celične smrti v normalnih in patoloških procesih ter z razvojem kliničnih raziskav na področju. Študenta pripraviti na pripravo projektov s tega področja biomedicine.

Splošne kompetence:
- obvladanje raziskovalnih metod in postopkov, razvoj kritične in samokritične presoje,
- sposobnost uporabe znanja v praksi,
- razvoj komunikacijskih sposobnosti in spretnosti, posebej komunikacije v mednarodnem okolju,
- kooperativnost, delo v skupini in tudi v mednarodnem okolju.

Predmetnospecifične kompetence:
Študent se bo seznanil s teoretičnimi osnovami problematike programirane celične smrti in z njenim pomenom in aplikacijami v biomedicinskih raziskavah. Pri svojem delu bo uporabljal najnovejšo tujo strokovno literaturo, kar bo izboljšalo njegove sposobnosti uporabe tujega jezika in kritičnega pogleda na objavljeno raziskovalno delo. Priprava na pripravo projektov s področja celične smrti.

To inform student with the basics of cell death, including types of cell death, mechanisms of action and regulation, with the role of cell death in normal and pathological conditions, as well as with the development of clinical studies. To prepare student for future design of projects from this area of biomedicine.

General Competences:
- the student will master research methods and procedures and develop skills for critical assessment of his activities,
- the student will be able to put his knowledge into practice,
- the student will develop communications skills to present research achievement in the international environment,
- training for team work including the work in international environment.

Course Specific Competences:
Student will learn theoretical background of programmed cell death and its relevance and application in biomedical research. During his study he will use the newest scientific literature, which will improve his foreign language skills and his ability to critically view the published research. Preparation for implementation into project preparation from the cell death field.

Predvideni študijski rezultati:

Intendeded learning outcomes:

Metode poučevanja in učenja:

Learning and teaching methods:

Načini ocenjevanja:

Delež v % / Weight in %

Assesment:

Seminar

50 %

Seminar

Ustni izpit

50 %

Oral exam

Reference nosilca / Lecturer's references:

1.	Hafner Cesen M, Repnik U, Turk V, Turk B. (2013) Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Cell Death Dis. 4:e818. doi: 10.1038/cddis.2013.361.
2.	Mikhaylov G, Klimpel D, Schaschke N, Mikac U, Vizovisek M, Fonovic M, Turk V, Turk B, Vasiljeva O (2014) Selective targeting of tumor and stromal cells by lipidated cathepsin B inhibitor-based drug delivery system. Angew. Chem. Intl. Ed. 53, 10077-10081.
3.	Repnik U, Hafner Cesen M, Turk B. (2014) Lysosomal membrane permeabilization in cell death: Concepts and challenges. Mitochondrion, 19 Pt A:49-57. doi: 10.1016/j.mito.2014.06.006.
4.	Taggart C, TURK B, et al. Protean proteases : at the cutting edge of lung diseases. European respiratory journal, ISSN 0903-1936, 2107, vol. 49, no. 2, 1501200-1-1501200-12, doi: 10.1183/13993003.01200-2015.
5.	KRAMER, Lovro, RENKO, Miha, ZAVRŠNIK, Janja, TURK, Dušan, SEEGER, Markus A., VASILJEVA, Olga, GRÜTTER, Markus G., TURK, Vito, TURK, Boris. Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin. Theranostics, ISSN 1838-7640, 2017, vol. 7, no. 11, str. 2806-2821, doi: 10.7150/thno.19081.