Učni načrt predmeta

Predmet:

Izbrana poglavja iz molekularne imunobiologije

Course:

Selected Topics in Molecular Immunobiology

Študijski program in stopnja / Study programme and level	Študijska smer / Study field	Letnik / Academic year	Semester / Semester
Nanoznanosti in nanotehnologije, 3. stopnja	Bioznanosti	1	1
Nanosciences and Nanotechnologies, 3RD cycle	Biosciences	1	1

Vrsta predmeta / Course type

Izbirni

Univerzitetna koda predmeta / University course code:

NANO3-894

Predavanja Lectures	Seminar Seminar	Vaje Tutorial	Klinične vaje work	Druge oblike študija	Samost. delo Individ. work	ECTS
15	15			15	105	5

*Navedena porazdelitev ur velja, če je vpisanih vsaj 15 študentov. Drugače se obseg izvedbe kontaktnih ur sorazmerno zmanjša in prenese v samostojno delo. / This distribution of hours is valid if at least 15 students are enrolled. Otherwise the contact hours are linearly reduced and transfered to individual work.

Nosilec predmeta / Course leader:

izr. prof. dr. Nataša Kopitar Jerala

Sodelavci / Lecturers:

Jeziki / Languages:

Predavanja / Lectures:

slovenski / angleški

Vaje / Tutorial:

Pogoji za vključitev v delo oz. za opravljanje študijskih obveznosti:

Prerequisits:

Vsebina:

Content (Syllabus outline):

Temeljna literatura in viri / Readings:

Učbeniki /Textbooks:
- Cellular and Molecular Immunology, 10th Edition - February 19, 2021 Abbas & Lichtman & Pillai, Saunders, ISBN: 9780323757485
- Janeway's Immunobiology,2016; Kenneth Murphy and Casey Weaver ;: ‎ Garland Science (March 22, 2016)  ISBN-10 ‏ : ‎ 0815345518

Ključni članki /Key articles to study:

-  Evavold  C.L. and Kagan J.C.  (2019).  Inflammasomes: Threat-Assessment Organelles of the Innate Immune System, Immunity 51, 609-624.
- Hopfner KP and   Hornung  V (2020) Molecular mechanisms and cellular functions of cGAS-STING signalling, Nat Rev Mol Cell Biol . 2020 Sep;21(9):501-521. 
doi: 10.1038/s41580-020-0244-x
- Paludan SR, Reinert  LS, Hornung V, DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer Nat Rev Immunol . 2019 Mar;19(3):141-153. doi: 10.1038/s41577-018-0117-0. 
- Broz, P., and Dixit, V.M. (2016). Inflammasomes: mechanism of assembly, regulation and signalling. Nat RevImmunol 16, 407-420.
- Deretic, V., Kimura, T., Timmins, G., Moseley, P., Chauhan, S., and Mandell, M. (2015). Immunologic manifestations of autophagy. The Journal of Clinical Investigation 125, 75-84.
- Ip, W.K.E., Hoshi, N., Shouval, D.S., Snapper, S., and Medzhitov, R. (2017). Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. Science 356, 513-519.
- Shibutani, S.T., Saitoh, T., Nowag, H., Munz, C., and Yoshimori, T. (2015). Autophagy and autophagy-related proteins in the immune system. Nat Immunol 16, 1014-1024.
- Yang, J., Zhao, Y., and Shao, F. (2015). Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity. Curr Opin Immunol 32, 78-83.
- Shiyu Xia 1 Zhibin Zhang , Venkat Giri Magupalli  et al. (2021) Gasdermin D pore structure reveals preferential release of mature interleukin-1, Nature 2021 May;593(7860):607-611. doi: 10.1038/s41586-021-03478-3

- Zaradi hitrosti razvijajočega se področja so temeljni študijski viri objavljeni članki v zadnjih letih, predvsem v
revijah Science, Nature, Nature Immunology, Immunity, Nature Reviews in Immunology; (kopije člankov bodo
na voljo študentom). / Because of the fast pace of development in this field, the fundamental learning resources are the most recently published articles, particularly those in the journals Science, Nature, Nature Immunology, Immunity, Nature Reviews in Immunology; (copies of the articles will be available to students).

Cilji in kompetence:

Objectives and competences:

Predvideni študijski rezultati:

Intendeded learning outcomes:

Metode poučevanja in učenja:

Learning and teaching methods:

Načini ocenjevanja:

Delež v % / Weight in %

Assesment:

Seminar

Ustno preverjanje

Oral assessment

Reference nosilca / Lecturer's references:

1.	SELKRIG, Joel, KOPITAR-JERALA, Nataša, TURK, Boris, et al. Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection. Nature microbiology, ISSN 2058-5276, 2020, vol. 5, no. 9, str. 1119%1133, doi: 10.1038/s41564-020-0736-7. [COBISS.SI-ID 24208643]
2.	BIASIZZO, Monika, TRSTENJAK-PREBANDA, Mojca, DOLINAR, Klemen, PIRKMAJER, Sergej, ZAVRŠNIK, Janja, TURK, Boris, KOPITAR-JERALA, Nataša. Cystatin C deficiency increases LPS-induced sepsis and NLRP3 inflammasome activation in mice. Cells, ISSN 2073-4409, 2021, vol. 10, iss. 8, str. 1-18, ilustr. https://www.mdpi.com/2073-4409/10/8/2071, doi: 10.3390/cells10082071. [COBISS.SI-ID 72910851],
3.	TRSTENJAK-PREBANDA, Mojca, ZAVRŠNIK, Janja, TURK, Boris, KOPITAR-JERALA, Nataša. Upregulation of mitochondrial redox sensitive proteins in LPS-treated stefin B-deficient macrophages. Cells, ISSN 2073-4409, 2019, vol. 8, no. 12, str. 1476-1-1476-13.
4.	BIASIZZO, Monika, KOPITAR-JERALA, Nataša. Interplay between NLRP3 inflammasome and autophagy. Frontiers in immunology, ISSN 1664-3224, 2020, vol. 11, str. 591803-1-591803-14, doi: 10.3389/fimmu.2020.591803. [COBISS.SI-ID 34284803]
5.	TRSTENJAK-PREBANDA, Mojca, MATJAN-ŠTEFIN, Petra, TURK, Boris, KOPITAR-JERALA, Nataša. Altered expression of peroxiredoxins in mouse model of progressive myoclonus epilepsy upon LPS-induced neuroinflammation. Antioxidants, ISSN 2076-3921, 2021, vol. 10, no. 3, str. 357-1-357-11, doi: 10.3390/antiox10030357. [COBISS.SI-ID 53380099],