Učni načrt predmeta

Predmet:

Proteazni degradom v napredovanju raka

Course:

Protease Degradome in Cancer Progression

Študijski program in stopnja / Study programme and level	Študijska smer / Study field	Letnik / Academic year	Semester / Semester
Nanoznanosti in nanotehnologije, 3. stopnja	Bioznanosti	1	1
Nanoscience and nanotechnologies, 3rd cycle	Biosciences	1	1

Vrsta predmeta / Course type

Izbirni / Elective

Univerzitetna koda predmeta / University course code:

NANO3-895

Predavanja Lectures	Seminar Seminar	Vaje Tutorial	Klinične vaje work	Druge oblike študija	Samost. delo Individ. work	ECTS
15	15			15	105	5

*Navedena porazdelitev ur velja, če je vpisanih vsaj 15 študentov. Drugače se obseg izvedbe kontaktnih ur sorazmerno zmanjša in prenese v samostojno delo. / This distribution of hours is valid if at least 15 students are enrolled. Otherwise the contact hours are linearly reduced and transfered to individual work.

Nosilec predmeta / Course leader:

prof. dr. Tamara Lah Turnšek

Sodelavci / Lecturers:

Jeziki / Languages:

Predavanja / Lectures:

Slovenščina, angleščina / Slovenian, English

Vaje / Tutorial:

Pogoji za vključitev v delo oz. za opravljanje študijskih obveznosti:

Prerequisits:

Vsebina:

Content (Syllabus outline):

Temeljna literatura in viri / Readings:

Izbrana poglavja iz naslednjih knjig: / Selected chapters from the following books:
Tannock IF, Breslo w RG, Hill RP, and Harrington L, The Basic Science of Oncology, McGraw-Hill MedPubl Div, 2013. ISBN: 978-0-07-181349-5 electronic and ISBN: 978-0-07-174520-8, MHID: 0-07-174520-3.
Weinberg RA- The Biology of Cancer, Garland Science, Taylor & Francis Grouip. LLC.USA., 2007. ISBN: 0-8153-4078-8.
Dylan E et al. (eds): Cencerdegradome - Proteases and Cancer biology, Springer. ISBN-978-0-387-69056-8.
Lah, T. T., Durán Alonso, M. B., & Van Noorden, C. J. F. (2006). Antiprotease therapy in cancer: hot or not? Expert Opinion on Biological Therapy, 6(3), 257–79. http://doi.org/10.1517/14712598.6.3.257.
Verbovšek, U., Van Noorden, C. J. F., & Lah, T. T. (2015). Complexity of cancer protease biology: Cathepsin K expression and function in cancer progression. Seminars in Cancer Biology. http://doi.org/10.1016/j.semcancer.2015.08.010.
Breznik, B., Motaln, H., & Turnšek, T. L. (2016). Proteases and cytokines as mediators of interactions between cancer and stromal cells in tumours. Biological Chemistry, 0(0). http://doi.org/10.1515/hsz-2016-0283.

Nature Reviews Cancer – review articles on selected topics in the filed of proteases & cancer

Cilji in kompetence:

Objectives and competences:

Predvideni študijski rezultati:

Intendeded learning outcomes:

Metode poučevanja in učenja:

Learning and teaching methods:

Načini ocenjevanja:

Delež v % / Weight in %

Assesment:

Ustni zagovor seminarske naloge

70 %

Oral defence of seminar work

Sodelovanje pri pripravah člankov ali seminarske naloge

30 %

Participation in preparation of scientific articles of seminar work

Reference nosilca / Lecturer's references:

1.	Podergajs, N., Motaln, H., Rajčević, U., Verbovšek, U., Koršič, M., Obad, N., … Turnšek, T. L. (2015). Transmembrane protein CD9 is glioblastoma biomarker, relevant for maintenance of glioblastoma stem cells.
2.	Breznik, B., Motaln, H., Vittori, M., Rotter, A., & Lah, T. (2017). Mesenchymal stem cells differentially affect the invasion of distinct glioblastoma cell lines. http://doi.org/10.18632/oncotarget.16041.
3.	Primon, M., Huszthy, P. C., Motaln, H., Talasila, K. M., Miletic, H., Atai, N. A., … Lah Turnšek, T. (2017). Cathepsin L silencing increases As 2 O 3 toxicity in malignantly transformed pilocytic astrocytoma MPA58 cells by activating caspases 3/7. Experimental Cell Research, 356(1), 64–73. http://doi.org/10.1016/j.yexcr.2017.04.013.
4.	Verbovšek, U., Van Noorden, C. J. F., & Lah, T. T. (2015). Complexity of cancer protease biology: Cathepsin K expression and function in cancer progression. Seminars in Cancer Biology. http://doi.org/10.1016/j.semcancer.2015.08.010.
5.	Molina, E. S., Pillat, M. M., Moura-Neto, V., Lah, T. T., & Ulrich, H. (2014). Glioblastoma stem-like cells: approaches for isolation and characterization. Journal of Cancer Stem Cell Research, 1(1), 1. http://doi.org/10.14343/JCSCR.2014.2e1007.