Department of Environmental Sciences (O2) invites you to a lecture by Prof. Dr. Gleb Sukhorukov (School of Engineering and Materials Science, Queen Mary, University of London) which will be held on Friday at 1 p.m. at the Kolar Lecture Hall, Jožef Stefan Institute, Jamova cesta 39, Ljubljana.
The talk reviews recent advances in micropackaging technologies with particular attention in areas of polyelectrolyte multilayer structures on patterned surfaces and colloidal particles, fabrication of microchambers with responsive properties and in vivo and intracellular applications of multilayer capsules. Alternating layering technology gives possibilities to tailor various functions to microstructures making them responsive to such factors as light, ultrasound or magnetic field. So called microchamber structures, made of polymer multilayers deposited onto imprinted stamps enable to accommodate various biologically active molecules. These chambers can be sealed with another thin hydrophobic polymer, such as polylactic acid layer and resulted structure is pulled off to form free standing microchambers. Entrapment of water soluble molecules into sealed chambers is achieved by precipitation from drying solution and formation of air micro-bubble once the chamber is sealed. These chambers can be externally activated releasing encapsulated cargo in time and site specific manner. For instance, local release could alter biological cells in close proximity of opened microchambers. Periodic structure made of sensitive polymers provides optically recordable sensor for physical and chemical factors such as temperature, humidity and pH based on simple diffraction.
Recent advances the polyelectrolyte capsules are focused on their role as confined geometries to synthesize carbon fluorescent nanoparticles which can provide new properties for multilayer films such as optical addressing and conductivity. The perspectives of biomedical applications of microcapsules are in capsule uptake by various cell types what opens possibilities to interfere intracellular process as well as cell magnetisation. For instance, mesenchymal stem cells once impregnated with magnetic capsules, can be navigated by magnetic field to particular sites for local differentiation and proliferation. Biological impact of cell assisted capsule delivery is discussed over possibility for cell tracking using photo-switchable capsules.